Publicações do Último Biênio envolvendo Equipamentos Multiusuário da Plataforma INFAR

Laboratório 1

VEIGA, A. C. et al. Renal nerves and hypertension contribute to impaired proximal tubule megalin-mediated albumin uptake in renovascular hypertensive rats. Hypertension Research, v. 48, n. 4, p. 1491–1502, 2025.

PACINI, E. S. A.; DE PAULA MORO, R.; GODINHO, R. O. Extracellular cAMP elicits contraction of rat vas deferens involvement of ecto 5 nucleotidase and adenosine A1 receptors. Toxicology and Applied Pharmacology, v. 491, p. 117070, 2024.

SATORI, N. A.; PACINI, E. S. A.; GODINHO, R. O. Impact of the cAMP efflux and extracellular cAMP adenosine pathway on airway smooth muscle relaxation induced by formoterol and phosphodiesterase inhibitors. Chemico Biological Interactions, v. 382, p. 110630, 2023.

TORQUATO, H. F. V. et al. DNA damage inducing 10 methoxy canthin 6 one promotes cell cycle arrest in G2 M and myeloid differentiation of acute myeloid leukemias and leukemic stem cells. ACS Omega, v. 9, n. 35, p. 37343–37354, 2024.

MINA, N. et al. How dendrimers impact fibrin clot formation structure and properties. ACS Omega, v. 9, p. 51306–51319, 2024.

Laboratório 3

TEIXEIRA, T. A. et al. Chronic scrotal content pain and viral orchiepididymitis an overlooked hypothesis linking infection and Wallerian degeneration. Basic and Clinical Andrology, v. 36, p. 6, 2026.

LEONEL BOONE, D. et al. Progressive generalized dystonia caused by a mutation in the MT ND6 gene. Parkinsonism and Related Disorders, v. 145, p. 108239, 2026.

KANAVOS, I. et al. What lies beyond thioredoxin reductase Cyclometallated gold compounds reveal Sec selectivity in glutathione peroxidases. Free Radical Biology and Medicine, v. 247, p. 139–156, 2026.

CHIARELLI, T. et al. Enhancing the bothropic antivenom through a reverse antivenomics approach. Journal of Proteome Research, v. 24, p. 881–890, 2025.

SILVA, F. A. A. et al. Screening inhibitory peptides against sphingomyelinase D from the livestock tick Rhipicephalus microplus using phage display technology. Biochimie, v. 236, p. 45–53, 2025.

MOLARI, W. S. et al. Amblyostatin 1 the first salivary cystatin with host immunomodulatory and anti inflammatory properties from the Neotropical tick Amblyomma sculptum. Frontiers in Immunology, v. 16, p. 1585703, 2025.

OLIVEIRA, P. et al. IL 6 degradation by secreted proteases from Paracoccidioides restrepiensis. International Journal of Microbiology, v. 2025, p. 5566307, 2025.

JULIANO, M. A. et al. 1,2,4 thiadiazolidin 3,5 diones as inhibitors of cysteine proteases. Molecules, v. 30, p. 3896, 2025.

SILVA, P. et al. The immunomodulatory and antitumor properties of the bacterial metalloprotease oligopeptidase A OpdA are mediated by TLR4 MyD88 TRIF and MAPK signaling pathways. Frontiers in Immunology, v. 16, p. 1, 2025.

GRUPENMACHER, A. T. et al. Antiangiogenic activity of 6 O desulfated modified heparin suppression of choroidal neovascularization. International Journal of Molecular Sciences, v. 26, p. 7673, 2025.

MENEGHETTI, M. C. Z. et al. Involvement of GTPases and vesicle adapter proteins in heparan sulfate biosynthesis. FEBS Journal, v. 292, p. 2237–2250, 2025.

LENZI, L. G. S. et al. Healing after Bruner and McCash incisions for limited fasciectomy in patients with Dupuytren disease a randomized clinical trial. Journal of Hand Surgery European Volume, v. 50, p. 898–906, 2025.

OLIVIERI, P. H. et al. Heparin binding proteins in the nanoparticle corona enhance cellular uptake through glycocalyx interactions. ACS Nano, v. 19, p. 42964–42978, 2025.

CORREA, T. et al. Nitric oxide modulates UDP evoked cytosolic transients via P2Y6 purinoceptor stimulation. Scientific Reports, v. 15, p. 41129, 2025.

MARAN, S. R. et al. Leishmania mexicana N acetyltransferase 10 is important for polysome formation and cell cycle progression. Molecular Microbiology, v. 123, p. 60–74, 2025.

DE AZAMBUJA, G. et al. Macrophage P2X4 receptors pathway is essential to persistent inflammatory muscle hyperalgesia onset and is prevented by physical exercise. PLoS One, v. 20, p. e0318107, 2025.

SEVERINO, M. B. et al. A CRISPR edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cells. Journal of Biological Chemistry, v. 301, p. 108308, 2025.

GASPAR, R. C. et al. Notch1 signalling is downregulated by aerobic exercise leading to improvement of hepatic metabolism in obese mice. Liver International, v. 45, p. e70068, 2025.

DE LIMA PENA, F. et al. Phenolic profile bioactivity and cytotoxicity of plant extracts from thyme ginger garlic roasted coffee and coffee silverskin. International Journal of Food Properties, v. 28, p. 2519843, 2025.

PONTE, L. G. S. et al. Beet leaves after in vitro digestion present antioxidant capacity and protective effects in colorectal cancer cells. Food Research International, v. 221, p. 117275, 2025.

JONES, A. J. et al. Head and neck cancer models promote age dependent musculoskeletal deterioration in mice. Scientific Reports, v. 15, p. 41639, 2025.

CASTELO BRANCO RAMOS NAKANDAKARI, S. et al. Supplementation with omega 3 ligand does not improve survival in murine sepsis models. American Journal of Physiology Endocrinology and Metabolism, v. 329, p. E663–E675, 2025.

SOUZA, D. S. et al. Signaling crosstalk of galectin 3 beta catenin and estrogen receptor in androgen independent prostate cancer cells. Journal of Steroid Biochemistry and Molecular Biology, v. 247, p. 106679, 2025.

AKHIGBE, T. M. et al. Does coenzyme Q10 improve semen quality and circulating testosterone level a systematic review and meta analysis. Frontiers in Pharmacology, v. 15, p. 1497930, 2025.

CARLOS, K. et al. The role of mitochondria in obstructive sleep apnea implications for upper airway muscles. International Journal of Molecular Sciences, v. 26, p. 10562, 2025.

LIVRAMENTO, J. B. et al. Protein nitration in patients with mitochondrial diseases. Antioxidants, v. 14, p. 211, 2025.

SERINO SILVA, C. et al. Proteomics and life history variability of endogenous phospholipases A2 inhibitors in Bothrops jararaca plasma. PLoS One, v. 19, p. e0295806, 2024.

COSTA, G. C. A. et al. Evaluation of the biological function of ribosomal protein S18 from cattle tick Rhipicephalus microplus. Ticks and Tick Borne Diseases, v. 15, p. 102333, 2024.

COSTA, G. C. A. et al. Functional characterization of a cystatin A from the bat Myotis davidii. Comparative Biochemistry and Physiology B, v. 274, p. 111003, 2024.

FERREIRA, G. C. et al. Sunflower trypsin monocyclic inhibitor selected for the main protease of SARS CoV 2 by phage display. Biological and Pharmaceutical Bulletin, v. 47, p. 1813–1822, 2024.

SANTORO, M. L. et al. Jararaca GPIb binding protein causes thrombocytopenia during Bothrops jararaca envenomation. Scientific Reports, v. 14, p. 31769, 2024.

PREATO, A. M. et al. The relevance of astrocytic cell culture models for neuroinflammation in neurodegeneration research. Neuroglia, v. 5, p. 27–49, 2024.

LENZI, L. G. S. et al. Alterations in proteoglycans and collagen correspond to progressive stages of Dupuytren disease. International Journal of Molecular Sciences, v. 25, p. 7192, 2024.

ONYEISI, J. O. S. et al. Effects of syndecan 4 silencing on extracellular matrix remodeling in anoikis resistant endothelial cells. Cell Biology International, v. 48, p. 883–887, 2024.

OLIVIERI, P. H. et al. Glycocalyx interactions modulate the cellular uptake of albumin coated nanoparticles. ACS Applied Bio Materials, v. 7, p. 7365–7377, 2024.

RAMOS DA SILVA GRILLO, V. T. et al. Nebulized enriched heparin improves respiratory parameters in patients with COVID 19 a randomized clinical trial. Scientific Reports, v. 14, p. 19902, 2024.

MACHERONI, C. et al. Estrogen receptor activates SRC and ERK1 2 and promotes tumorigenesis in testicular carcinoma cells. Experimental Cell Research, v. 442, p. 114282, 2024.

MACHERONI, C. et al. Activation of estrogen receptor induces proteomic responses related to migration invasion and tumor development. Journal of Steroid Biochemistry and Molecular Biology, v. 237, p. 106443, 2024.

BELPIEDE, L. T. et al. Transgenerational effects of melatonin deficiency on metabolism and thermoregulation in offspring. Melatonin Research, v. 7, p. 134–152, 2024.

RAMOS, V. M. et al. Mitochondrial sodium calcium exchanger regulates autophagy through calcium signaling. FASEB Journal, v. 38, p. e23454, 2024.

CALIARI, A. B. et al. Self assembly cytocompatibility and interactions of desmopressin with sodium polystyrene sulfonate. Soft Matter, v. 20, p. 9597–9613, 2024.

Laboratório 4, 5 e 6

Microscópio Confocal SP8 – Leica

SCHARF, Pablo; SANDRI, Silvana; RIZZETTO, Felipe; XAVIER, Luana Filippi; GROSSO, Daniela; CORREIA-SILVA, Rebeca D.; FARSKY, Pedro S.; GIL, Cristiane D.; FARSKY, Sandra Helena Poliselli. GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients. Frontiers in Immunology, v. 15, p. 1–13, 2024.

CORREIA-SILVA, Rebeca D.; CORRÊA, MAB P.; RODRIGUES-SILVA, Nathália; SANTOS, Diego D.; D’ÁVILA, Solange C. G. P.; GRECO, Karin V.; GIL, Cristiane D. Functional role of Annexin A1 and S100A11 in psoriasis pathogenesis: insights from IMQ-induced models and keratinocyte modulation. International Immunopharmacology, v. 159, p. 114915, 2025.

LICE, Izabella; ITO, Henrique T. K.; CORREIA-SILVA, Rebeca D.; SANTOS, Diego D.; SASSO, Gisela R. S.; FRANCO, Paulo C.; ARTIGIANI, Ricardo; GRECO, Karin V.; GIL, Cristiane D. Exploring the therapeutic potential of annexin A1-derived peptide Ac2-26 in modulating NLRP3 inflammasome activation in Crohn’s disease. Molecular and Cellular Biochemistry, v. 1, p. 1, 2025.

CORREIA-SILVA, Rebeca D.; CORRÊA, MAB P.; DE CASTRO, Maria Eduarda; ALMEIDA, Joaquim S.; D’ÁVILA, Solange C. G. P.; OLIANI, Sonia M.; GRECO, Karin V.; GIL, Cristiane D. Regulatory role of annexin A1 in NLRP3 inflammasome activation in atopic dermatitis: insights from keratinocytes in human and murine studies. Journal of Molecular Medicine, v. 1, p. 1, 2025.

CASSANO, D. A. et al. AgRP neuron activity enhances reward-related consummatory behaviors during energy deficit in mice. Communications Biology, v. 8, n. 1, p. 1152, 2025.

FERREIRA, N. L. et al. Leptin signaling in POMC neurons regulates plasma leptin levels and is critical to mediate hypothalamic-pituitary-adrenal axis activation during fasting. Scientific Reports, v. 15, n. 1, p. 25574, 2025.

ROMARIZ, S. et al. Neuroprotective and anti-inflammatory effects of cannabidiol in rats submitted to severe traumatic brain injury. Heliyon, v. 12, e44708, 2026.

SANABRIA, V. et al. Chronic effects of traumatic brain injury and the impact of Biperiden treatment in a male rat model. Experimental Neurology, v. 398, p. 1–11, 2026.

AZEVEDO, C. V. et al. Distinct effects of long-term resistance exercise on cognitive deficits, neurotrophins and amyloid pathology in male and female APP/PS1 mice. Journal of Alzheimer’s Disease, 2025.

BRAGA, M. et al. Effects of acute Biperiden treatment following traumatic brain injury in male rats. Scientific Reports, v. 15, p. 1–17, 2025.

ROMARIZ, S. et al. High concentrations of cannabidiol induce neurotoxicity in neurosphere culture system. Neurotoxicity Research, v. 42, n. 1, p. 1–14, 2024.

TAVARES, M. R. et al. Role of Kinin B2 receptor signaling in astrocyte-driven neuroinflammation. Cellular and Molecular Neurobiology, v. 46, n. 1, p. 38, 2026.

MINA, N. et al. How dendrimers impact fibrin clot formation, structure, and properties. ACS Omega, v. 9, n. 52, p. 51306–51319, 2024.

MINA, N. et al. Ultrasmall nanoparticles bind to fibrinogen and impair normal clot formation. Particle & Particle Systems Characterization, v. 41, n. 4, p. 2300107, 2024.

OLIVIERI JR., P. H. et al. Heparin-binding proteins in the nanoparticle corona enhance cellular uptake through glycocalyx interactions. ACS Nano, v. 19, n. 51, p. 42964–42978, 2025.

PINTO-MARTINEZ, A. et al. HSP70 governs permeability and mechanotransduction in primary human endothelial cells. FEBS Open Bio, v. 16, n. 2, p. 382–396, 2026.

PARDO-DÍAZ, C. et al. Effects of ZnO/Cu and bioactive glass-modified universal adhesives on biological properties, bond strength, and interfacial stability under cariogenic challenge. Clinical Oral Investigations, v. 30, n. 3, p. 99, 2026.

PEREIRA, L. M. et al. The self-assembling peptide P11-4 induces the expression of mineralization-related genes in odontoblasts independently of metabolic alterations. Journal of Functional Biomaterials, v. 17, n. 1, p. 50, 2026.

DAMASCENO, E. S. C. et al. Calcium silicate particles biological and mechanical role in the hybrid layer. Journal of Dental Research, v. 104, n. 12, p. 1343–1351, 2025.

PARDO-DÍAZ, C. et al. Bioactive and antibacterial universal adhesives containing ZnO/Cu and bioactive glass nanoparticles. Journal of Dentistry, v. 167, p. 106524, 2026.

Microscópio Confocal LSM780 – Zeiss

ERUSTES, A. G. et al. Cannabidiol induces autophagy via CB1 receptor and reduces α-synuclein cytosolic levels. Brain Research, v. 1850, p. 149414, 2025.

Citômetro FACSCalibur – BD

PIVETTA, R. S. et al. PD-L1 downregulation by carbonic anhydrase IX immunotherapy prompts immune checkpoint blockade in renal cell carcinoma. European Journal of Pharmaceutical Sciences, v. 213, p. 107190, 2025.

PACHECO DE CAMPOS, N. S. et al. Carbonic anhydrase IX and cyclooxygenase-2 regulation in renal cell carcinoma and impact on therapeutic efficiency of anti-CAIX CAR T cells. Current Topics in Medicinal Chemistry, 2025.

TORQUATO, H. F. V. et al. DNA damage-inducing 10-methoxy-canthin-6-one promotes cell cycle arrest in G2/M and myeloid differentiation.

SANTOS, W. et al. Protein restriction impairs the response activation/responsivity of MAPK signaling pathway of hematopoietic stem cells. Nutrition Research, v. 116, p. 12–23, 2023.